In related to their failure to stop health care reform from passing last night, the Republicans have set their sights on a new goal: Speaker of the House is Nancy Pelosi.

It has been replaced by boasting a goal to knock the Democratic leader from her post by winning 40 seats in the House of Representatives in November's elections.

"It is time to fire Nancy Pelosi and send a message to President Barack that it's time to stop their partisan liberal agenda of government takeovers and start working for Americans to create jobs and grow our economy," said in a statement late last night.

The site aims to raise $402,010 in 40 hours. As of this posting, the total had reached $278,684. The donators are invited to give as little as $40, but as much as $400.

While Republicans demonize the House Speaker with the Web site, are praising her and the passage of health care reform from Democrats .

Chairman Tim Kaine said "President Obama and Congressional Democrats accomplished something that has eluded Presidents, Congress and the American people for decades."

"We owe great thanks to the President, Speaker Pelosi, Majority Leader Reid and their leadership teams."

This is not the first time Pelosi has been targeted by the GOP. Last year, the National Republican Congressional Committee spearheaded a Fire Nancy Pelosi petition using mobile phones. The goal was to obtain signatures, but also raise money.

Nancy Pelosi, a California congresswoman first elected to the House in 1987, is the nation's first female to hold the position of Speaker.